Category: Experimental Solutions

Revolutionize Your Sectioning Workflow: Introducing the Removable Buffer Tray for Compresstome®

We are thrilled to announce a major upgrade for our precision sectioning community: the Removable Buffer Tray system. Designed to streamline your research and simplify machine maintenance, this new accessory offers unparalleled flexibility for your Compresstome® VF-510-0Z workflow. Why Go Removable? Traditionally, fixed tube bases required more time-intensive cleaning and setup. Our new removable system […]

Written by on January 27, 2026

Why Researchers Are Choosing the Compresstome Over Cryostats

Simplify your tissue sectioning. Preserve integrity. Eliminate freezing artifacts. Traditional cryostats have long been the go-to tool for tissue sectioning, but they come with significant drawbacks—freezing damage, bulky design, and intensive maintenance. The Compresstome VF-510-0Z offers a modern alternative: a next-generation vibrating microtome that enables fast, reliable sectioning of live or fixed tissues—without the need […]

Written by on November 4, 2025

Sectioning Organoids with Precision: How the Compresstome Enables Advanced 3D Tissue Research

The Growing Role of Organoids in Research Organoids are transforming biomedical research. These three-dimensional, multicellular models mimic the architecture and function of real human tissues, making them invaluable for studying complex processes such as organ development, cancer progression, and regenerative therapies. Derived from stem cells or primary tissues, organoids maintain the spatial organization, cellular diversity, […]

Written by on June 3, 2025

New Protocol Guide: Everything You Need to Know About Precision-Cut Lung Slices (PCLS)

Explore our detailed manual for mastering PCLS in respiratory research We’re thrilled to announce the launch of our comprehensive Precision-Cut Lung Slices Protocol Manual—a practical, researcher-friendly guide designed to help you get consistent, healthy lung tissue slices every time. Whether you’re just getting started with PCLS or are looking for ways to refine your technique, this […]

Written by on April 25, 2025

Learn the Basics About Antigen Retrieval!

At Precisionary Instruments, because so many of our tissue slicer users handle fixed tissue, we often get asked about antigen retrieval. Today, we’d like to cover this as a short explanatory topic! What is antigen retrieval and why is it important? Have you ever worked with fixed tissue? If you process tissue slices for immunological […]

Written by on March 31, 2025

A Comprehensive Step-by-Step Guide to Acute Brain Slices for Electrophysiology

At Precisionary Instruments, we understand that preparing acute brain slices for electrophysiology is a highly technical and delicate process. Many researchers have reached out to us, looking for a clear and structured protocol that walks them through every step. In response, we have developed a detailed, step-by-step experimental guide, one of the first of its […]

Written by on March 26, 2025

Introducing the SteadyHold Tube Stabilizer: A Game-Changer for Tissue Embedding

Are you struggling to keep your specimen tube secure? Do you need a dependable solution for sample embedding? Wish you had a “third hand” to help? If you’ve ever faced the challenge of keeping your specimen tube steady while embedding tissue, we have the perfect solution. Introducing the SteadyHold Tube Stabilizer—Precisionary Instruments’ latest innovation designed […]

Written by on March 7, 2025

New Year, New Slicer: Try Our Compresstome Vibratome Demo Program

Starting the year with fresh research goals? If improving your tissue sectioning workflow is a priority, our 30-day demo program for the Compresstome VF-510-0Z is the perfect opportunity to explore a vibratome that sections tissue faster, preserves sample integrity, and simplifies your lab work. We understand that some institutions require a demo before purchasing, and […]

Written by on February 28, 2025

Enhancing Neurophysiological Research with the Vibratome Electrophysiology Kit for Acute Brain Slices [UPDATED]

Acute brain slices are a cornerstone of neurophysiological research, providing an essential platform for investigating neuronal activity through techniques like patch-clamp electrophysiology. The preparation of these delicate tissue slices requires precision, care, and specialized tools to preserve their viability and functionality. Understanding the challenges neurophysiologists face, we are excited to introduce the Compresstome Vibratome Electrophysiology […]

Written by on February 21, 2025

Understanding ACSF: A Crucial Solution for Electrophysiology and Acute Brain Slice Maintenance

Artificial Cerebrospinal Fluid (ACSF) is an essential buffer solution widely used in electrophysiology experiments, particularly to keep acute brain slices alive during research. This solution closely mimics the natural cerebrospinal fluid found in the brain and is designed to maintain neuronal viability and function during experiments like patch-clamp recordings. In this article, we’ll explore the […]

Written by on September 10, 2024