Upcoming Webinar | April 14 | Mechanisms of Microglia-Mediated Neurodegeneration in Alzheimer’s Disease
Pioneering RNA Therapeutics for Liver Diseases Dr. Gordon Jiang, a transplant hepatologist and physician-scientist at Beth Israel Deaconess Medical Center and Harvard Medical School, leads a research program focused on tackling some of the most challenging aspects of liver disease. His lab is dedicated to understanding the mechanisms behind liver failure—especially the role of transcriptional […]
At Precisionary Instruments, our mission is to provide cutting-edge tissue sectioning solutions for researchers around the world. Behind every high-performance vibratome, microtome, and cryostat is a team of dedicated engineers who work tirelessly to ensure precision, durability, and usability. Today, we’re excited to spotlight Sam Moss, an engineer whose expertise and problem-solving skills help drive […]
Advancing skin research depends on high-quality tissue samples, and a recent study (Ziolkowski et al. from Science Advances) is a great example of how innovative sectioning techniques can make a big difference. This team of researchers set out to better understand touch detection in skin tissue, and to do that, they needed clear, precise sections […]
Hi there! As Chief Scientific Officer at Precisionary Instruments, I’ve had the privilege of working with countless researchers to optimize their tissue sectioning for immunohistochemistry (IHC). Whether you’re studying protein localization, cellular structures, or disease markers, the quality of your tissue sections can make or break your experiment. One of the most common questions I […]
Artificial Cerebrospinal Fluid (ACSF) is an essential buffer solution widely used in electrophysiology experiments, particularly to keep acute brain slices alive during research. This solution closely mimics the natural cerebrospinal fluid found in the brain and is designed to maintain neuronal viability and function during experiments like patch-clamp recordings. In this article, we’ll explore the importance of ACSF, its composition, and practical tips to optimize its use.
If you’re involved in tissue sectioning, you’ve probably heard the terms “vibrating microtome” and “vibratome” thrown around quite a bit. Spoiler alert: they’re actually the exact same thing! But let’s dive a bit deeper into what these nifty laboratory tools are, their history, and how Precisionary Instruments has made some game-changing improvements over the years […]
Vibratome for High-Throughput Tissue Sectioning Have you ever wanted to make one cut and get enough tissue slices for an entire 24-well plate? Well, our new Compresstome® VF-800-0Z is now capable of doing exactly that! For instance, just ONE tissue section can yield 20 to 30 or more samples, easily filling an entire 24-well plate […]
Microtome, vibratome, vibrating microtome…you’ve heard so many different terms for this type of laboratory equipment. Let us help you clear up any confusions in terminology! Defining microtome vs vibratome A microtome is a device used to cut very thin slices of tissue, called sections, for examination under a microscope. It typically uses a sharp, stationary […]
