Tag: Vibratome

The Stability Advantage: Why Agarose Embedding Outperforms Standard Mounting

At Precisionary Instruments, our engineering philosophy is built on a single premise: stability equals quality. This is why the Compresstome® is designed specifically to utilize agarose embedding for every tissue specimen. While traditional vibratomes often rely on a single point of adhesion to a flat stage, the Compresstome® is engineered to work with an agarose […]

Written by on March 9, 2026

Lab Spotlight: Mapping Cell-Type Vulnerability in the Hippocampus with Precision Tissue Sectioning

Members of the Bienkowski Lab at the USC Center for Integrative Connectomics, which combines spatial transcriptomics, circuit mapping, and imaging to understand how distinct brain cell types are affected in disease. Meet the Bienkowski Lab at the USC Center for Integrative Connectomics Dr. Michael S. Bienkowski is an Assistant Professor of Physiology and Neuroscience and […]

Written by on January 27, 2026

Revolutionize Your Sectioning Workflow: Introducing the Removable Buffer Tray for Compresstome®

We are thrilled to announce a major upgrade for our precision sectioning community: the Removable Buffer Tray system. Designed to streamline your research and simplify machine maintenance, this new accessory offers unparalleled flexibility for your Compresstome® VF-510-0Z workflow. Why Go Removable? Traditionally, fixed tube bases required more time-intensive cleaning and setup. Our new removable system […]

Written by on January 27, 2026

Lab Spotlight: Heidi Kreckel & the Levinger Lab – Visualizing Cryoprotectant Uptake in Plant Tissues

Introducing the Levinger Lab and PhD Candidate Heidi Kreckel At Colorado State University, the Levinger Lab—led by Professor Nancy E. Levinger—has long been a pioneer in exploring how molecules behave in nanoconfined environments. Recently, the Levinger group has added studies exploring how plant material can withstand cryoprotectant treatments that help it survive at ultralow temperatures.   […]

Written by on January 26, 2026

Precisionary Instruments Expands Global Reach with Launch of Precisionary Europe

Precisionary Europe Is Here to Support Our Researchers! We’re excited to share an important announcement: Precisionary Instruments now has an official European presence—Precisionary Europe! 🎉 For years, our Compresstome® vibratomes have been helping researchers around the world make breakthroughs in neuroscience, physiology, cancer biology, and many other fields. In Europe, our valued partners at Red […]

Written by on October 15, 2025

Lab Spotlight: Dr. Virginia Puente

Advancing Neuroscience Through Live Imaging of the Brain’s Extracellular Space We are honored to spotlight the work of Dr. Virginia Puente, an MSCA and María Zambrano researcher at the University of the Basque Country (UPV/EHU). A pharmacist by training, Dr. Puente leads an ambitious and innovative research program centered on understanding how the extracellular space […]

Written by on July 10, 2025

Precisionary Instruments Partners with Agilent to Advance Live Tissue Metabolic Analysis

Integrating the Compresstome® Vibrating Microtome into the Agilent Seahorse XF Flex Tissue Workflow ASHLAND, Mass., June 3, 2025 — Precisionary Instruments today announced a strategic partnership with Agilent to enhance the preparation of live tissue slices for use with the Agilent Seahorse XF Flex Analyzer and 3D Capture Microplate. This collaboration integrates Precisionary’s Compresstome® VF-510-0Z […]

Written by on June 3, 2025

Sectioning Organoids with Precision: How the Compresstome Enables Advanced 3D Tissue Research

The Growing Role of Organoids in Research Organoids are transforming biomedical research. These three-dimensional, multicellular models mimic the architecture and function of real human tissues, making them invaluable for studying complex processes such as organ development, cancer progression, and regenerative therapies. Derived from stem cells or primary tissues, organoids maintain the spatial organization, cellular diversity, […]

Written by on June 3, 2025

New Protocol Guide: Everything You Need to Know About Precision-Cut Lung Slices (PCLS)

Explore our detailed manual for mastering PCLS in respiratory research We’re thrilled to announce the launch of our comprehensive Precision-Cut Lung Slices Protocol Manual—a practical, researcher-friendly guide designed to help you get consistent, healthy lung tissue slices every time. Whether you’re just getting started with PCLS or are looking for ways to refine your technique, this […]

Written by on April 25, 2025