Organ: Brain (Live or Acute)

Modulation of Neuronal Signaling by Brain Extracellular Space Structure and Dynamics

Dr. Virginia Puente is a neuroscientist whose work focuses on how the structure and dynamics of the brain’s extracellular space (ECS) modulate neuronal signaling. Her research integrates advanced tools including optogenetics, fluorescence imaging, and super-resolution techniques like STED microscopy and SUSHI (Super-resolution Shadow Imaging) to examine neuronal excitability and synaptic plasticity.

Written by on April 22, 2025

Genetic Manipulation of the Mouse Developing Hypothalamus Through In Utero Electroporation

Researchers have used the Compresstome® in their procedure to section mouse embryo hypothalamus that has been injected with DNA and electroporated. This procedure demonstrates how it is possible to transfect nuclei in the hypothalamus region which are less accessible than those in superficial regions. Following this procedure additional experiments can be performed such as immunohistochemistry and in situ hybridization.

Written by on April 25, 2023