Tag: compresstome

Lab Spotlight: Dr. Virginia Puente

Advancing Neuroscience Through Live Imaging of the Brain’s Extracellular Space We are honored to spotlight the work of Dr. Virginia Puente, an MSCA and María Zambrano researcher at the University of the Basque Country (UPV/EHU). A pharmacist by training, Dr. Puente leads an ambitious and innovative research program centered on understanding how the extracellular space […]

Written by on July 10, 2025

Precisionary Instruments Partners with Agilent to Advance Live Tissue Metabolic Analysis

Integrating the Compresstome® Vibrating Microtome into the Agilent Seahorse XF Flex Tissue Workflow ASHLAND, Mass., June 3, 2025 — Precisionary Instruments today announced a strategic partnership with Agilent to enhance the preparation of live tissue slices for use with the Agilent Seahorse XF Flex Analyzer and 3D Capture Microplate. This collaboration integrates Precisionary’s Compresstome® VF-510-0Z […]

Written by on June 3, 2025

Sectioning Organoids with Precision: How the Compresstome Enables Advanced 3D Tissue Research

The Growing Role of Organoids in Research Organoids are transforming biomedical research. These three-dimensional, multicellular models mimic the architecture and function of real human tissues, making them invaluable for studying complex processes such as organ development, cancer progression, and regenerative therapies. Derived from stem cells or primary tissues, organoids maintain the spatial organization, cellular diversity, […]

Written by on June 3, 2025

New Protocol Guide: Everything You Need to Know About Precision-Cut Lung Slices (PCLS)

Explore our detailed manual for mastering PCLS in respiratory research We’re thrilled to announce the launch of our comprehensive Precision-Cut Lung Slices Protocol Manual—a practical, researcher-friendly guide designed to help you get consistent, healthy lung tissue slices every time. Whether you’re just getting started with PCLS or are looking for ways to refine your technique, this […]

Written by on April 25, 2025

A Comprehensive Step-by-Step Guide to Acute Brain Slices for Electrophysiology

At Precisionary Instruments, we understand that preparing acute brain slices for electrophysiology is a highly technical and delicate process. Many researchers have reached out to us, looking for a clear and structured protocol that walks them through every step. In response, we have developed a detailed, step-by-step experimental guide, one of the first of its […]

Written by on March 26, 2025

Employee Spotlight: Alyssa MacDonald, Engineering Technician

At Precisionary Instruments, our team is the backbone of innovation in tissue sectioning technology. In this employee spotlight, we introduce Alyssa MacDonald, one of our talented Engineering Technicians, who plays a crucial role in ensuring the quality and precision of our vibratomes. A Hands-On Path to Engineering Alyssa’s journey into engineering is unique. With a […]

Written by on March 26, 2025

Meet the Team: Engineering Excellence with Sam Moss at Precisionary Instruments

At Precisionary Instruments, our mission is to provide cutting-edge tissue sectioning solutions for researchers around the world. Behind every high-performance vibratome, microtome, and cryostat is a team of dedicated engineers who work tirelessly to ensure precision, durability, and usability. Today, we’re excited to spotlight Sam Moss, an engineer whose expertise and problem-solving skills help drive […]

Written by on March 24, 2025

Vibrating Microtome vs. Vibratome: Understanding the Similarities and Differences

If you’re involved in tissue sectioning, you’ve probably heard the terms “vibrating microtome” and “vibratome” thrown around quite a bit. Spoiler alert: they’re actually the exact same thing! But let’s dive a bit deeper into what these nifty laboratory tools are, their history, and how Precisionary Instruments has made some game-changing improvements over the years […]

Written by on July 22, 2024

How sex hormones sculpt the brain

Sex hormones are hormones that play a role in the development and maintenance of the male and female reproductive systems, as well as secondary sexual characteristics. There are two main categories of sex hormones: androgens and estrogens. Androgens are responsible for the development and maintenance of male characteristics. The main androgen in males is testosterone, […]

Written by on May 29, 2023

Types of Microtome Blades

Microtome blades are used in microtomes to cut thin slices, or sections, of biological tissue samples for microscopic examination. These slices are typically less than 50 micrometers thick and are utilized for a variety of critical purposes, including histological analysis, tissue culture, and electron microscopy. The use of precision cutting blades allows for absolute control […]

Written by on May 15, 2023