Upcoming Webinar | October 20 | A Multi-Scale Neuroscience Approach to CNS Therapeutic Target Discovery
Figure. Members of the Raimondo Lab, Department of Human Biology, University of Cape Town. Meet the Raimondo Lab at the University of Cape Town The Raimondo Lab is based in the Division of Cell Biology, Department of Human Biology, at the University of Cape Town’s medical campus in South Africa, led by Associate Professor Joseph […]
Key Takeaways The tail striatum (TS) is a poorly understood brain region linked to sensory processing, and its medium spiny neurons (MSNs) have never been characterized electrophysiologically in depth — until now. TS-MSNs are electrophysiologically distinct from dorsolateral striatum (DLS) MSNs, with more depolarized resting potentials, lower rheobase, and stronger spontaneous excitatory input. The three […]
Key Takeaways Two doses of psilocybin administered before chemotherapy prevented peripheral neuropathy in mice for up to eight months, without impairing the anti-tumor efficacy of the chemotherapy itself. The neuroprotective effect required serotonin 2A receptor activation but not the drug’s hallucinogenic properties. A nonhallucinogenic 2A agonist worked equally well, opening a practical path to clinical […]
Key Takeaways Kv3.1b potassium channel expression increases substantially in the dorsal cochlear nucleus (DCN) of mice after the onset of hearing, but this upregulation does not explain why individual action potentials become shorter and faster during development. Instead, increased Kv3.1b expression specifically supports the ability of DCN fusiform neurons to sustain high-frequency firing,a capacity critical […]
Key Takeaways Synthetic cooling agents WS-3 and WS-23 — widely used as menthol substitutes in e-cigarettes — significantly enhance nicotine self-administration behavior in mice, matching the reinforcing effects of menthol itself. These coolants boost dopamine release in the nucleus accumbens core, increase the excitability of dopamine neurons in the ventral tegmental area, and amplify nicotine-induced […]
Precisionary Europe is hosting a free one-day masterclass on tissue slicing in Dublin on July 2, 2026. Featuring a keynote by Dr. Yiying Zhang (Harvard Medical School / MGH) on the gut-brain axis, live hands-on time with the Compresstome VF-510-0Z, and methodology discussions across multiple organ systems. Seating is limited — register free at Eventbrite. […]
At Precisionary Instruments, our engineering philosophy is built on a single premise: stability equals quality. This is why the Compresstome® is designed specifically to utilize agarose embedding for every tissue specimen. While traditional vibratomes often rely on a single point of adhesion to a flat stage, the Compresstome® is engineered to work with an agarose […]
In the world of precision tissue sectioning, the Compresstome® is a powerful engine, but the quality of the final slice often depends on the “fuel” and the “handling”—the environment in which a sample is sliced and the specialized tools used to manipulate it. Whether the goal is to maintain the firing of a neuron or […]
Simplify your tissue sectioning. Preserve integrity. Eliminate freezing artifacts. Traditional cryostats have long been the go-to tool for tissue sectioning, but they come with significant drawbacks—freezing damage, bulky design, and intensive maintenance. The Compresstome VF-510-0Z offers a modern alternative: a next-generation vibrating microtome that enables fast, reliable sectioning of live or fixed tissues—without the need […]
At Precisionary Instruments, we understand that preparing acute brain slices for electrophysiology is a highly technical and delicate process. Many researchers have reached out to us, looking for a clear and structured protocol that walks them through every step. In response, we have developed a detailed, step-by-step experimental guide, one of the first of its […]
