Upcoming Webinar | August 4 | Using Surgically Resected Brain Tissue to Study the Physiological Maturation of Human Neurons
Key Takeaways A new study from Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School, generated with Precisionary’s Compresstome vibrating microtome, extends viable human precision-cut liver slice (PCLS) culture to 10 to 14 days, far beyond the field baseline where fewer than 7% of published PCLS studies maintain culture past 72 hours. During extended […]
From precision-cut slices to spatial multi-omics: how modern renal research cuts and reads kidney tissue Kidney tissue sectioning has moved well beyond the microtome and glass slide. As renal research shifts toward models that preserve living, multicellular architecture, the way we cut and maintain kidney tissue has become a scientific variable in its own right. […]
Formulas and rationale for live sectioning of brain, heart, lung, liver, organoids, and tumors There is no universal buffer. Start from six requirements every sectioning buffer shares (isotonic ~300 mOsm, pH 7.3 to 7.4, balanced ions, glucose, oxygenation, ice-cold), then add tissue-specific protectants. Brain: carbogen-bubbled aCSF; switch to an NMDG- or sucrose-substituted aCSF for cutting […]
Key Takeaways Researchers profiled how SMARCB1-deficient sinonasal carcinoma responds to drugs directly in patient tumor tissue, preserving the spatial architecture rather than dissociating the sample. Live tumor slices were generated on a Compresstome tissue slicer, producing uniform, viable sections suitable for ex vivo drug exposure. Drug responses varied across distinct regions of the same tumor, […]
At Precisionary Instruments, our ultimate goal is to support scientists throughout their careers and we absolutely love following them as they become successful in their respective fields. There is nothing more rewarding than partnering with brilliant minds, watching their projects evolve, and celebrating their monumental milestones. Today, we are thrilled to shine a Lab Spotlight […]
Precisionary Europe is hosting a free one-day masterclass on tissue slicing in Dublin on July 2, 2026. Featuring a keynote by Dr. Yiying Zhang (Harvard Medical School / MGH) on the gut-brain axis, live hands-on time with the Compresstome VF-510-0Z, and methodology discussions across multiple organ systems. Seating is limited — register free at Eventbrite. […]
At Precisionary Instruments, our engineering philosophy is built on a single premise: stability equals quality. This is why the Compresstome® is designed specifically to utilize agarose embedding for every tissue specimen. While traditional vibratomes often rely on a single point of adhesion to a flat stage, the Compresstome® is engineered to work with an agarose […]
In the world of precision tissue sectioning, the Compresstome® is a powerful engine, but the quality of the final slice often depends on the “fuel” and the “handling”—the environment in which a sample is sliced and the specialized tools used to manipulate it. Whether the goal is to maintain the firing of a neuron or […]
Members of the Bienkowski Lab at the USC Center for Integrative Connectomics, which combines spatial transcriptomics, circuit mapping, and imaging to understand how distinct brain cell types are affected in disease. Meet the Bienkowski Lab at the USC Center for Integrative Connectomics Dr. Michael S. Bienkowski is an Assistant Professor of Physiology and Neuroscience and […]
We are thrilled to announce a major upgrade for our precision sectioning community: the Removable Buffer Tray system. Designed to streamline your research and simplify machine maintenance, this new accessory offers unparalleled flexibility for your Compresstome® VF-510-0Z workflow. Why Go Removable? Traditionally, fixed tube bases required more time-intensive cleaning and setup. Our new removable system […]
